ANALYSIS OF MICRORNA BIOMARKERS AS PREDICTIVE VALUES FOR CERVICAL CANCER TREATMENT, IN RELATIONSHIP WITH ENVIRONMENTAL EXPOSURE TO ARSENIC, PHTHALATES AND COTININE
Cervicall-arsen-array is an inter and multidisciplinary research project under the requirements of the program PN-II-PT-PCCA-2011-3, coordinated by the Oncology Institute “Prof Dr Ion Chiricuta” Cluj-Napoca. The main goal of the Project is to elaborate a prediction model for therapy response (pharmacogenomics) of patients with advanced cervical cancer (stage IIB-IIIB) based on tissue and serum genomic signature (miRNA-microarray) and to investigate if toxic exposure to mixture (arsenic, phthalates and cotinine as a ETS biomarker) could influence the treatment response General objective: elaborate a prediction model for therapy response in patients with advanced cervical cancer.
The specific objectives of the project are: O1. Identification of specific miRNA signature in response to concurrent chemo radiotherapy in patients with stage IIB-IIIB cervical cancer as predictive molecules to treatment outcome; O2. Explore a possible correlation of miRNA signatures in tumor biopsies with the ones from serum samples in order to develop a noninvasive prediction test; O3. Investigate if and how the exposure to arsenic, phthalates and cotinine mixtures of the patients with cervical cancer could influence the treatment response
Duration of the project:
- Oncology Institute “Prof Dr Ion Chiricuta” Cluj-Napoca (CO)
- University of Medicine and Pharmacy Cluj-Napoca (1)
- Environmental Health Center Cluj-Napoca (P2)
- Babes Bolyai University Cluj-Napoca (P3)
The final result of the project was the development of a prediction model for therapy response in patients with advanced cervical cancer (stage IIB-IIIB) based on tissue and serum genomics signature (miRNA) related to a pharmacogenomics and PBPK prediction prototype.